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Hypertension complicating131I-meta-iodobenzylguanidine therapy for neuroblastoma

✍ Scribed by Michael A. Kosmin; Jamshed B. Bomanji; Nicholas J. Cork; Ananth Shankar; Mark N. Gaze


Book ID
113026265
Publisher
Springer
Year
2012
Tongue
English
Weight
258 KB
Volume
39
Category
Article
ISSN
0340-6997

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Treatment of advanced neuroblastoma with
✍ Alberto Garaventa; Dr. Bruno De Bernardi; Edoardo Lanino; Paolo Guerra; Mario Be πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 635 KB

31 children with advanced pretreated neuroblastoma were treated with 131-1 meta-Iodobenzylguanidine (131-MIBG). Thirteen children had been resistant to first-line therapy, three had suffered a local relapse, and fourteen had suffered a disseminated relapse without overt bone marrow infiltration. On

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Toxic effects from 131I-meta-iodobenzylguanidine (131I-MIBG) treatments of neuroblastoma in six patients were recorded. The toxicity was largely confined to the hematologic system where circulating leukocytes and platelets regularly declined after each dose of 131I-MIBG; the values reached nadirs be