Hypertension complicating131I-meta-iodobenzylguanidine therapy for neuroblastoma
β Scribed by Michael A. Kosmin; Jamshed B. Bomanji; Nicholas J. Cork; Ananth Shankar; Mark N. Gaze
- Book ID
- 113026265
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 258 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0340-6997
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31 children with advanced pretreated neuroblastoma were treated with 131-1 meta-Iodobenzylguanidine (131-MIBG). Thirteen children had been resistant to first-line therapy, three had suffered a local relapse, and fourteen had suffered a disseminated relapse without overt bone marrow infiltration. On
Toxic effects from 131I-meta-iodobenzylguanidine (131I-MIBG) treatments of neuroblastoma in six patients were recorded. The toxicity was largely confined to the hematologic system where circulating leukocytes and platelets regularly declined after each dose of 131I-MIBG; the values reached nadirs be