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Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response

✍ Scribed by Yunfeng Han; XiaoHan Fan; Kai Sun; Xiaojian Wang; Yibo Wang; Jingzhou Chen; Yisong Zhen; Weili Zhang; Rutai Hui


Book ID
118430486
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
162 KB
Volume
44
Category
Article
ISSN
0009-9120

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Novel polymorphic AluYb8 insertion in th
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Mutations in __WNK1__ and __WNK4__ cause familial hypertension, the Gordon syndrome. __WNK1__ and __WNK4__ conserved noncoding regions were targeted to polymorphism screening using DHPLC and DGGE. The scan identified an undescribed polymorphic __AluYb8__ insertion in __WNK1__ intron 10. Screening in