Hyperstranded DNA Architectures Observed by Cold-Spray Ionization Mass Spectrometry

✍ Scribed by Shigeru Sakamoto; Kentaro Yamaguchi

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 803 KB
• Volume: 42
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200390239

✦ Synopsis

washing manipulations in the entire array. Significantly, the efficiency of the synthesis does not depend on the number of building blocks used along each axis. This feature provides a unique advantage of this method over the use of 2D arrays, representing a direct alternative to the split synthesis. [9] Although the operational simplicity of the split synthesis exceeds that of the present method, the ability to spatially resolve and positionally encode individual library members offered by the current approach compares favorably with the split synthesis, which requires additional encoding-decoding operations. [10,11] Extension of the work presented herein to the development of suitable systems for the synthesis of 1000-10 000-membered small-molecule libraries is in progress and will be reported in due course.