Hyperpolarization is not responsible for the acetylcholine-induced negative chronotropic action in the presence of isoproterenol

MCL-1, a member of the BCL-2 family, is

MCL-1, a member of the BCL-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferation

✍ Tao Yang; Heather L. Buchan; Karen J. Townsend; Ruth W. Craig 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 1008 KB

mcl-1 was identified as an "early-induction" gene that increases in expression during the differentiation of ML-1 human myeloblastic leukemia cells. The mcl-1 gene product proved to be a member of the bcl-2 gene family and, like bcl-2, to have the capacity to promote cell viability. The pattern of e