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Hypermethylation associated with inactivation of theSOCS-1gene, a JAK/STAT inhibitor, in human hepatoblastomas

✍ Scribed by H. Nagai; T. Naka; Y. Terada; T. Komazaki; A. Yabe; E. Jin; O. Kawanami; T. Kishimoto; N. Konishi; M. Nakamura; Y. Kobayashi; M. Emi

Book ID: 106252860
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 284 KB
Volume: 48
Category: Article
ISSN: 1435-232X
DOI: 10.1007/s100380300008

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## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator