## Abstract Dementia is a frequent non‐motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa‐treated patients with PD. The objective of our study was
Hyperhomocysteinemia recurrence in levodopa-treated Parkinson’s disease patients
✍ Scribed by V. Belcastro; L. Pierguidi; A. Castrioto; C. Menichetti; G. Gorgone; R. Ientile; F. Pisani; A. Rossi; P. Calabresi; N. Tambasco
- Book ID
- 111066219
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 95 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1351-5101
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## Abstract Homocysteine, cysteine, and cysteinyl‐glycine are all metabolically interrelated. Levodopa/decarboxylase inhibitor (LD/DCI) administration increases total homocysteine (tHcy) plasma levels. Objectives were to investigate associations between LD/DCI intake, concentrations of tHcy, cystei
The effect of levodopa on the mortality of patients with Parkinson's disease was investigated in 349 patients treated with levodopa or levodopa combined with decarboxylase inhibitor during 1969-1975 inclusive. During the study period, 61 patients died. The expected mortality was 32.99 resulting in a