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Hypergranular promyelocytic leukemia: correlation between morphology and chromosomal translocations including t(15;17) and t(11;17)

✍ Scribed by Bennett, J M; Catovsky, D; Daniel, M-T; Flandrin, G; Galton, D A G; Gralnick, H R; Willman, C L


Book ID
110054572
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
266 KB
Volume
14
Category
Article
ISSN
0887-6924

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A reciprocal chromosomal translocation, t( I 5; I7)(q22;q I I .2-I2), is characteristic of acute promyelocytic leukemia (APL) of French-American-British (FAB) subtype M3, and is not associated with any other human malignancy. The non-random pattern of the APL translocations suggests that specific ge