Hyperfractionated radiotherapy and polychemotherapy in brain stem tumors in children

✍ Scribed by B. Pakisch; C. Urban; I. Slavc; E. Poier; G. Stücklschweiger; R. Oberbauer; M. Mokry; J. Poschauko; J. Hammer; H. Leitner; A. Hackl

• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 452 KB
• Volume: 8
• Category: Article
• ISSN: 0256-7040
• DOI: 10.1007/bf00262849

✦ Synopsis

Between October 1989 and January 1991 five children with brain stem tumors were treated with sequential chemo- and radiotherapy. The polychemotherapy consisted of procarbazine, ifosfamide, etoposide, methotrexate, cisplatin and cytosine arabinoside. Locally, hyperfractionated radiotherapy was delivered at a total dose of 63.8 Gy (1.1 Gy twice daily, 10 fractions per week). After a median observation time of 11.8 (range 4-23) months from diagnosis three children are alive and without evidence of tumor progression. Two patients died from tumor progression 11 and 16 months respectively after initiation of therapy.