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Hyperfractionated radiation therapy (72 Gy) for children with brain stem gliomas A childrens cancer group phase I/II trial

โœ Scribed by Roger J. Packer; James M. Boyett; Robert A. Zimmerman; Lucy B. Rorke; Allen M. Kaplan; A. Leland Albright; Michael T. Selch; Jonathan L. Finlay; G. Denman Hammond; William M. Wara


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
748 KB
Volume
72
Category
Article
ISSN
0008-543X

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## BACKGROUND. Prognosis for the majority of children with brain stem gliomas is dismal. In previous studies, recombinant beta-interferon (@IF) has been shown to be effective for children with recurrent brain stem gliomas and may also act synergistically with radiotherapy (RT). ## METHODS. Thir

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## BACKGROUND. Efforts to improve local control and survival by increasing the dose of once-daily radiation therapy beyond 70 Gray (Gy) for patients with malignant gliomas have as yet been unsuccessful. Hyperfractionated radiation therapy (HF) should allow for delivery of a higher total dose witho