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Hyperforin and its analogues inhibit CYP3A4 enzyme activity

✍ Scribed by Ju-young Lee; Rujee K. Duke; Van H. Tran; James M. Hook; Colin C. Duke

Book ID
108242523
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
220 KB
Volume
67
Category
Article
ISSN
0031-9422

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## Abstract CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer ch