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Hyperexcretion of free N-acetylneuraminic acid — a novel type of sialuria

✍ Scribed by J. Palo; H. Rauvala; J. Finne; M. Haltia; K. Palmgren


Book ID
115824923
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
422 KB
Volume
145
Category
Article
ISSN
0009-8981

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A new synthesis of N-acetylneuraminic ac
✍ René Csuk; Martin Hugener; Andrea Vasella 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 German ⚖ 649 KB

A new synthesis of N-acetylneuraminic acid (NeuSAc; 28) via the aldehyde 10 is described. The aldehyde 10 was obtained from N-acetyl-o-glucosamine (11; 5 steps, overall yield ca. 6 %) or from o-glucono-1,s-lactone (17; 6 steps, overall yield ra. 57%). Thus, on the one hand, N-acetyl-D-mannosamine (1