Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood
β Scribed by M. J. Humphrey; J. J. Hutter Jr.; W. W. Tom
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 413 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0361-8609
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We report the prenatal diagnosis of a transient myeloproliferative disorder suggestive of leukaemia in a fetus with hepatosplenomegaly, hydrops and 47, XY,+21 karyotype. The initial fetal white blood cell count at 26+5 weeks' gestation was 190/nl with 70 per cent blast cells. Immunophenotyping of th
Cytologic, immunologic, and cytogenetic studies were performed on the blast cells of a newborn with Down syndrome and transient myeloproliferative disease. This hematologic disorder is uncommon, and occurs primarily in infants with Down syndrome. This boy presented with a high white blood cell count