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Hypercalcemia in idiopathic myelofibrosis: Modulation of calcium and collagen homeostasis by 1,25-dihydroxyvitamin D3

✍ Scribed by A. Voss; K. Schmidt; H. Hasselbalch; P. Junker

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 227 KB
Volume: 39
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830390316

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✦ Synopsis

Abstract

A case of idiopathic myelofibrosis (IMF) presenting with hypercalcemia and hypercalcitriolemia is reported. It is proposed that ectopic production of the active vitamin D metabolite related to ongoing clonal expansion in the bone marrow accounts for the hypercalcemic state. Consistently low levels of circulating type I procollagen propeptide (PICP) and lack of progression of the bone marrow fibrosis during almost 6 months of follow‐up point to an in vivo inhibition of type I collagen synthesis by 1,25‐dihydroxyvitamin D3.

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