Hyperbranched Polyamidoamines Containing β-Cyclodextrin for Controlled Release of Chlorambucil

✍ Scribed by Yuanyuan Zhou; Zhe Guo; Yongwen Zhang; Wei Huang; Yongfeng Zhou; Deyue Yan

• Book ID: 102474266
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 230 KB
• Volume: 9
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200900110

✦ Synopsis

Abstract

This work is focused on the controlled drug release behavior of hyperbranched HPMA in the presence of β‐CD. Hence, three HPMA‐β‐CDs and a pure HPMA were synthesized by Michael addition polymerization. As a model drug, CLB (an anti‐cancer drug) was loaded into them via a solution method for in vitro release studies. The DSC results indicate that the CLB/polymer interactions are at the molecular level. Loading CLB into these polymers results in an evident increase in their glass transition temperatures, and Δ__T__~g~ depends on the β‐CD content. The controlled‐release experiments show that the presence of β‐CD can appropriately slow the release of CLB from HPMA‐β‐CDs and adjust the ratio of CLB released in total drug loading.

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