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Hyperbaric oxygen suppressed ERK1/2 and p38 MAPK mediate nitric oxide-induced apoptosis on human degenerated intervertebral disc cells

โœ Scribed by C.-C. Niu; C.-Y. Yang; I.-C. Wang; L.-J. Yuan; S.-S. Lin; W.-J. Chen

Book ID
116324429
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
65 KB
Volume
48
Category
Article
ISSN
8756-3282

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โœ Chi-Chien Niu; Li-Jen Yuan; Lih-Huei Chen; Song-Shu Lin; Tsung-Ting Tsai; Jen-Ch ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 159 KB

## Abstract Nucleus pulposus cells (NPCs) from degenerating disks produce catabolic and inflammatory factors, including interleukin (IL)โ€1, nitric oxide (NO), prostaglandin E2 (PGEโ€2), and matrix metalloproteinaes (MMPs). An imbalance between MMPs and tissue inhibitors of matrix metalloproteinases