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Hyperaminoacidemia in epileptic children treated with valproic acid

✍ Scribed by M. Castro-Gago; E. Rodrigo-Saez; I. Novo-Rodriguez; M. F. Camiña; S. Rodriguez-Segade

Publisher
Springer
Year
1990
Tongue
English
Weight
278 KB
Volume
6
Category
Article
ISSN
0256-7040

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✦ Synopsis

Serum amino acids were determined in 22 epileptic children treated with valproic acid. This treatment caused hypocarnitinemia in all, and hyperammonemia in 16. Regardless of the blood ammonia levels, values for glutamic acid, arginine, glycine, serine and alanine were higher than those of normal controls, while aspartic acid and ornithine were lower. These findings suggest that valproate causes intramitochondrial dysfunction of the urea cycle.

📜 SIMILAR VOLUMES

Hyperamino-acidaemia and hyperammonaemia
Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid
✍ K. Iinuma; K. Hayasaka; K. Narisawa; K. Tada; K. Hori 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 313 KB

Serum amino acid pattern, blood ammonia, and serum valproic acid (VPA) levels were estimated in 75 epileptic children with and without VPA therapy. The incidence of patients with hyperammonaemia (greater than 60 mumol/l) in patients treated with only VPA or with a combination of VPA and other antiep