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Hyperalgesia and upregulation of cytokines and nerve growth factor by cutaneous leishmaniasis in mice

✍ Scribed by Salim A. Kanaan; Nayef E. Saadé; Mark Karam; Hala Khansa; Suhayl J. Jabbur; Abdo R. Jurjus

Book ID: 117480531
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 400 KB
Volume: 85
Category: Article
ISSN: 0304-3959
DOI: 10.1016/s0304-3959(99)00297-3

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Intraspinal and behavioral events were studied in adult rats with nociceptive nerves that were undergoing collateral sprouting into adjacent denervated skin. This sprouting, which is driven by endogenous nerve growth factor (NGF), did not cause hyperalgesia. For comparison, we studied an exogenous N