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Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression

✍ Scribed by J. Prathiba; K. B. Kumar; K. S. Karanth


Publisher
Springer
Year
1998
Tongue
English
Weight
63 KB
Volume
105
Category
Article
ISSN
1435-1463

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Novel approaches to the treatment of dep
✍ TimothyG Dinan 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 53 KB

Many patients with major depression show evidence of over-activation of the hypothalamic - pituitary - adrenal axis (HPA), as evidenced by hypercortisolism and adrenal hyperplasia. Such over-activity is associated with increased corticotropin releasing factor (CRF) reactivity in the CSF and blunted