Hyper-reactivity of mouse CD45RA − T cells
✍ Scribed by Elizabeth Lightstone; Jacqueline Marvel; Avrion Mitchison
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 414 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0014-2980
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📜 SIMILAR VOLUMES
Peripheral CD4 + T cells can be divided into two different functional populations based on the expression of distinct isoforms of the surface molecule CD45. We have investigated the differences in the proximal signaling induced by anti-CD3 monoclonal antibody in purified populations of "naive" CD45R
## Abstract T cell activation requires costimulation of TCR/CD3 plus accessory receptors (__e.g.__ CD28). A hallmark of costimulation is the dynamic reorganization of the actin cytoskeleton, important for receptor polarization in the immunological synapse. The classical model of T cell costimulatio