The use of solid dispersions for oral dosage forms can increase the dissolution rate of poorly soluble drugs. Spray drying is one process that can be used to prepare solid dispersions. Spray dried solid dispersions of griseofulvin, poly[N-(2-hydroxypropyl)methacrylate] (PHPMA) and polyvinylpyrrolido
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Hygroscopic stability and dissolution properties of spray-dried solid dispersions of furosemide with eudragit
โ Scribed by Makoto Otsuka; Mika Onoe; Yoshihisa Matsuda
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 712 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0022-3549
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Solid dispersions were prepared of itraconazole-Eudragit E100, itraconazole-PVPVA64, and itraconazole-Eudragit E100/PVPVA64 using a corotating twin-screw hot-stage extruder. Modulated temperature differential scanning calorimetry (MTDSC) was used to evaluate the miscibility of the extrudates, and di