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Hydroxyurea use during pregnancy: A case report in sickle cell disease and review of the literature

✍ Scribed by Diav-Citrin, Orna; Hunnisett, Laura; Sher, Graham D.; Koren, Gideon

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 19 KB
Volume: 60
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199902)60:2<148::aid-ajh12>3.0.co;2-i

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✦ Synopsis

A patient being treated for sickle cell disease with hydroxyurea (1 g/d) conceived, and drug treatment was discontinued at nine weeks gestational age. The pregnancy and delivery were complicated by vaso-oclusive crises. A healthy male infant was born at 39 weeks with no evidence of congenital malformations. A literature review, including this case, suggests that the risk of hydroxyurea exposure during in pregnancy may have been overestimated. Further studies are required to determine its safety in pregnancy.

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