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Hydroxyurea: The drug of choice for polycythemia vera and essential thrombocythemia

โœ Scribed by David Dingli; Ayalew Tefferi


Book ID
107540151
Publisher
Current Science Inc.
Year
2006
Tongue
English
Weight
103 KB
Volume
1
Category
Article
ISSN
1558-8211

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In polycythemia Vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%. This risk has been estimated to be 1-5.9% with hydroxyurea (HU) therapy. When compared with historical controls, the risk with use of HU does not a