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Hydroxyurea inhibits ODC induction, but not the G1 to S phase transition

✍ Scribed by Anne E. Cress; Eugene W. Gerner


Book ID
118314140
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
410 KB
Volume
87
Category
Article
ISSN
0006-291X

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## Abstract Ornithine decarboxylase, an important enzyme in growth regulation, is increased in CHO cells in G~1~ phase of the cell cycle and decreases as the cells progress into S phase. S‐adenosyl‐L‐methionine decarboxylase activity, which is dependent on either the presence of putrescine or sperm