Hydroxyurea Induces Site-specific DNA Damage via Formation of Hydrogen Peroxide and Nitric Oxide

Heme induces DNA damage and hyperprolife

Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: A possible mechanism of heme-induced colon cancer

✍ Shin-ichi Ishikawa; Satoru Tamaki; Motoko Ohata; Keizo Arihara; Makoto Itoh 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 339 KB

## Abstract Epidemiological and animal model studies have suggested that high intake of heme, present in red meat, is associated with an increased risk of colon cancer. However, the mechanisms underlying this association are not clear. This study aimed to investigate whether heme induces DNA damage