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Hydroxyurea-induced oxidative damage of normal and sickle cell hemoglobins in vitro: Amelioration by radical scavengers

✍ Scribed by Efe W. Iyamu; Hugo Fasold; Dante Roa; Maria del Pilar Aguinaga; Toshio Asakura; Ernest A. Turner

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 80 KB
Volume: 15
Category: Article
ISSN: 0887-8013
DOI: 10.1002/1098-2825(2001)15:1<1::aid-jcla1>3.0.co;2-i

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✍ D. Roa; P. Kopsombut; M. d. P. Aguinaga; E. A. Turner 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 104 KB 👁 2 views

Use of hydroxyurea (HU) to treat sickle cell disease is usually associated with increments in fetal hemoglobin (Hb F) production; however, in vitro studies show that HU may also induce hemoglobin denaturation. Whole blood samples from Hb AA, Hb AS, and Hb SS patients were treated in vitro with 100,