Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells
β Scribed by Brun, M; Bourdoulous, S; Couraud, P O; Elion, J; Krishnamoorthy, R; Lapoumeroulie, C
- Book ID
- 110075257
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 355 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1470-269X
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Endothelin-1 (ET-1) is a potent vasoconstrictor peptide synthesized and secreted by vascular endothelial cells. Regulation of ET-1 production occurs at the level of gene transcription. We previously demonstrated a role for arachidonic acid as an intracellular mediator in the regulation of gene expre
## Republic of China Vascular endothelial cells (ECs) are constantly subjected to mechanical strain due to relaxation and contraction of vessel walls. The effects of cyclical strain on endothelin-1 (Et-1) secretion and Et-1 mRNA levels in human umbilical vein ECs were examined. Cultured ECs grown