Inhibition of agitation-induced aggregat
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Tim Serno; John F. Carpenter; Theodore W. Randolph; Gerhard Winter
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Article
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2010
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John Wiley and Sons
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English
⚖ 280 KB
In order to provide an alternative to nonionic surfactants as excipients for protein formulations, cyclodextrin-derivatives (CDs) were examined for their potential to inhibit agitation-induced aggregation of an IgG in aqueous solution. Loss of monomeric protein and protein aggregation were monitored