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Hydroxypropyl-β-cyclodextrin inhibits spray-drying-induced inactivation of β-galactosidase

✍ Scribed by Sébastien Branchu; Robert T. Forbes; Peter York; Sven Petrén; Håkan Nyqvist; Ola Camber


Book ID
109389240
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
121 KB
Volume
88
Category
Article
ISSN
0022-3549

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In order to provide an alternative to nonionic surfactants as excipients for protein formulations, cyclodextrin-derivatives (CDs) were examined for their potential to inhibit agitation-induced aggregation of an IgG in aqueous solution. Loss of monomeric protein and protein aggregation were monitored