Hydroxypropyl Chitosan Bearing β-Cyclodextrin Cavities: Synthesis and Slow Release of its Inclusion Complex with a Model Hydrophobic Drug

✍ Scribed by Mani Prabaharan; João F. Mano

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 194 KB
• Volume: 5
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200500087

✦ Synopsis

Abstract

Summary: Hydroxypropyl chitosan‐graft‐carboxymethyl β‐cyclodextrin (HPCH‐g‐CM β‐CD) was synthesized by grafting CM β‐CD onto HPCH using water soluble 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide (EDC) as the condensing agent. Due to the presence of hydrophobic β‐CD rings onto the HPCH backbone, this polymer can be used as a matrix for controlled drug release. The adsorption of a hydrophobic model drug, ketoprofen, by HPCH‐g‐CM β‐CD microparticles (using tripolyphosphate as an ionic crosslinking agent) fitted well in the Langmuir isotherm equation. The drug dissolution profile showed that HPCH‐g‐CM β‐CD microparticles provided a slower release of the entrapped ketoprofen than chitosan, and the release behavior was influenced by the pH value of the medium. These results suggest that β‐CD grafted with chitosan derivatives may become a potential biodegradable delivery system to control the release of hydrophobic drugs with pH‐responsive capability.

The structure and drug release profiles of HPCH‐g‐CM β‐CD.

magnified imageThe structure and drug release profiles of HPCH‐g‐CM β‐CD.