## Abstract Previous studies have demonstrated that the NADHβdependent cytochrome b~5~ electron transfer pathway can support some cytochrome P450 monooxygenases in vitro in the absence of their normal redox partner, NADPHβcytochrome P450 oxidoreductase. However, the ability of this pathway to suppo
β¦ LIBER β¦
Hydroxylation products of hydrophobic xenobiotics and cytochrome P-450 stabilizers in hepatocytes
β Scribed by K. N. Novikov; R. I. Viner; A. M. Dudchenko; A. T. Ugolev; L. D. Luk'yanova; V. E. Kagan
- Publisher
- Springer US
- Year
- 1984
- Tongue
- English
- Weight
- 360 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0007-4888
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The aim of this study was to test suitable culture conditions for maintaining normal cellular cytoarchitecture and inducibility of P450 enzymes in primary cultures of human hepatocytes by prototypical inducers. The selectivity and sensitivity of a sandwich culture system were determined by treating