✦ LIBER ✦
Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae
✍ Scribed by Yongquan Xue; Daniel Wilson; Lishan Zhao; Hung-wen Liu; David H Sherman
- Book ID
- 104375761
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 923 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1074-5521
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✦ Synopsis
Background: Streptomyces venezuelae produces two groups of antibiotics that include the 12-membered ring macrolides methymycin and neomethymycin, and the 14-membered ring macrolide pikromycin. Methymycin and pikromycin are derived from the corresponding precursors, YC-17 and narbomycin,