Hydroxylation of Guanine in Nucleosides and DNA at the C-8 Position by Heated Glucose and Oxygen Radical-Forming Agents

Identification of three major DNA adduct

Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine

✍ Volker M. Arlt; Heinz H. Schmeiser; Martin R. Osborne; Masanobu Kawanishi; Takah 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 483 KB

## Abstract 3‐Nitrobenzanthrone (3‐NBA) is a potent mutagen and potential human carcinogen identified in diesel exhaust and ambient air particulate matter. Previously, we detected the formation of 3‐NBA‐derived DNA adducts in rodent tissues by ^32^P‐postlabeling, all of which are derived from reduc