Hydroxylamine anion — an effective α-nucleophile in acyl transfer reactions
✍ Scribed by Yu. S. Simanenko; A. F. Popov; T. M. Prokop'eva; V. A. Savelova; I. A. Belousova
- Book ID
- 112365981
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 264 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-5760
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📜 SIMILAR VOLUMES
Nucleophile specificity of subtilisin (subtilopeptidase A) was studied via acyl transfer reactions in acetonitrile containing piperidine and 10 vol% of water. Ac-Tyr-OEt was used as acyl donor and a series of amino acid derivatives, diand tripeptides of the general structure Xaa-Gly, Gly-Xaa, Gly-Gl
The magnitude of the a-effect for reactions of 4-nitrophenyl substituted benzoates with a pair of anionic nucleophiles is independent of the electronic nature of the acyl substituent, while the one for the corresponding reactions with a pair of neutral nucleophiles increases as the acyl substituent