✦ LIBER ✦

Hydroxyl groups at C-3 and at C-17 of the unnatural enantiomer, ent-androsta-5,9(11)-diene-3β,17β-diol are oxidised by cholesterol oxidase from Rhodococcus erythropolis

✍ Scribed by Dai Kitamoto; Serge Dieth; Alain Burger; Denis Tritsch; Jean-François Biellmann

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 72 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)02005-0

No coin nor oath required. For personal study only.

✦ Synopsis

The ent-androsta-4,9(11)-diene-3b,17b-diol 1b and ent-androsta-5,9(11)-diene-3b,17b

-diol 2b prepared from chiral dione 3, were oxidised by cholesterol oxidase with kinetic parameters close to those of the natural steroids 1a and 2a. In the preparative oxidation the final product was ent-androsta-4,9(11)-diene-3,17-dione 5. So the enzyme catalysed the oxidation of the hydroxyl groups at C-3 and C-17, whereas the natural enantiomers were only oxidised at C-3.

📜 SIMILAR VOLUMES

ChemInform Abstract: Hydroxyl Groups at

ChemInform Abstract: Hydroxyl Groups at C-3 and at C-17 of the Unnatural Enantiomer, ent-Androsta-5,9(11)-diene-3β,17β-diol Are Oxidized by Cholesterol Oxidase from Rhodococcus erythropolis.

✍ Dai Kitamoto; Serge Dieth; Alain Burger; Denis Tritsch; Jean-Francois Biellmann 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views