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Hydroxycarbamide-induced changes in E/beta thalassemia red blood cells

โœ Scribed by Sylvia T. Singer; Elliott P. Vichinsky; Sandra Larkin; Nancy Olivieri; Nancy Sweeters; Frans A. Kuypers


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
110 KB
Volume
83
Category
Article
ISSN
0361-8609

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Hydroxyurea (HU) is an effective drug for the treatment of sickle cell disease (SCD). The main clinical benefit of HU is thought to derive from its capacity to increase fetal hemoglobin (HbF) production. However, other effects leading to clinical benefit, such as improved blood rheology, have been s