Hydroxamic acids II: Kinetics and mechanisms of hydroxyaminolysis of succinimide
β Scribed by Robert E. Notari
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 572 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3549
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β¦ Synopsis
Factors affecting the stability of the hydroxamic acid-iron complex have been studied. It has been shown that the iron concentration is the most important factor for complex stability.
Conditions for a stable complex have been developed and found to be superior to those utilizing HzOz.
An assay for succinimide has been designed and found to be reproducible on consecutive days.
The hydroxyaminolysis reaction has been successfully carried out in an aqueous medium. Therefore the assay is potentially useful for pharmaceutical systems.
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The kinetic stopped flow method has been used to study the reaction rates of Ni(I1) and Pd(I1) with methioninehydroxamate (Mx). Two reaction rates were observed in the MX-Ni(I1) system whereas three rates were observed in the MX-Pd(II) system. Most of the rate steps were dependent on pH as well as o
Rates of reaction for the alkaline hydrolysis of various hydroxamic acids in the presence of cetyltrimethylammonium bromide have been determined. Empirical reaction orders of zero, one-half, and one were found for the hydroxamic acids depending upon reaction conditions and substrate structure. N-met