Hydroxamate Inhibitors ofAeromonas hydrophilaAE036 Metallo-B-lactamase

✍ Scribed by Magnus W. Walter; Maria Hernandez Valladares; Robert M. Adlington; Gianfranco Amicosante; Jack E. Baldwin; Jean-Marie Frère; Moreno Galleni; Gian Maria Rossolini; Christopher J. Schofield

• Book ID: 102564951
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 86 KB
• Volume: 27
• Category: Article
• ISSN: 0045-2068
• DOI: 10.1006/bioo.1998.1111

✦ Synopsis

Amino acid derived hydroxamates were synthesized and tested for inhibitory activity against different metallo-␤-lactamases. Several compounds inhibited the clinically relevant enzyme from Aeromonas hydrophila AE036.