A potential use for phenylisothiocyanate (PITC), the most popular Edman reagent, is presented for analysis of the amino acid sequence and configuration in peptides containing oiL-amino acids. After derivatization with PITC of the A'-terminal amino acid (L-TY~) of an enkephalin analogue, [D-Ala', o-L
Hydrophobicity of Peptides Containing D-Amino Acids
β Scribed by Toratane Munegumi
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 156 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1612-1872
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A series of oligopeptides containing aromatic and basic residues were synthesized and their interactions with double-stranded nucleic acids studied by proton and phosphorus NMR, viscometry, and DNA melting temperature (T m ). The oligopeptides prepared contain two aromatic amino acids (phenylalanine
This is the second of five books in the *Amino Acids, Peptides and Proteins in Organic Synthesis* series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino