Hydrophobic Aided Replica Exchange: an Efficient Algorithm for Protein Folding in Explicit Solvent †

Application of biasing-potential replica

Application of biasing-potential replica-exchange simulations for loop modeling and refinement of proteins in explicit solvent

✍ Srinivasaraghavan Kannan; Martin Zacharias 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 683 KB

## Abstract Comparative or homology modeling of a target protein based on sequence similarity to a protein with known structure is widely used to provide structural models of proteins. Depending on the target‐template similarity these model structures may contain regions of limited structural accur