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Hydrophilicity/ lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

✍ Scribed by B.A. Hamelin; J. Turgeon


Book ID
117341558
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
200 KB
Volume
19
Category
Article
ISSN
0165-6147

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πŸ“œ SIMILAR VOLUMES


Relative lipophilicities, solubilities,
✍ Abu T. M. Serajuddin; Sunanda A. Ranadive; Eileen M. Mahoney πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 532 KB

The apparent octanol-water partition coefficients (Po/w) and aqueous solubilities for four 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors [pravastatin, lovastatin (mevinolin), mevastatin (compactin), and simvastatin (synvinolin)] were compared. Pravastatin is highly hydrophilic