Hydrophilic cholesterol-binding molecular imprinted polymers

✍ Scribed by Ning Zhong; Hoe-Sup Byun; Robert Bittman

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 73 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00045-4

✦ Synopsis

Novel hydrophilic molecularly imprinted polymers (MIPs) were prepared using acryloyl-containing hydrophilic monomers (including cholesteryl acrylate (CA) and acryloyl-6-amino-6-deoxy-b (or g)-cyclodextrin), and their steroid-binding properties were analyzed in 2-PrOH by HPLC. The MIPs bound 38-50 mmol of cholesterol/g, while the corresponding nonimprinted control polymers (containing no CA) bound only 6-9 mmol cholesterol/g. The sterol-binding selectivity was illustrated with estrone, which was bound by MIPs in the range 5-36 mmol/g.