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Hydroperoxide-mediated cytochrome P450-dependent 8-anilino-1-naphthalenesulfonic acid destruction, product formation and P450 modification

✍ Scribed by Xuan-Chuan Yu; Henry W. Strobel

Book ID
110242786
Publisher
Springer
Year
1997
Tongue
English
Weight
115 KB
Volume
167
Category
Article
ISSN
0300-8177

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Interactions of cytochrome P450 2B1 were probed using 8-anilino-1-naphthalenesulfonic acid (ANS), a well known and frequently used reporter group for hydrophobic interactions. Titration of cytochrome P450 2B1 with ANS revealed 6.6 +/- 0.2 ANS binding sites per molecule of P450 2B1 with a Kd value of