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Hydrolysis of oxaliplatin—evaluation of the acid dissociation constant for the oxalato monodentate complex

✍ Scribed by Elin Jerremalm; Staffan Eksborg; Hans Ehrsson

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
68 KB
Volume
92
Category
Article
ISSN
0022-3549

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✦ Synopsis

Alkaline hydrolysis of the platinum anticancer drug oxaliplatin gives the oxalato monodentate complex and the dihydrated oxaliplatin complex in two consecutive steps. The acid dissociation constant for the oxalato monodentate intermediate was determined by a kinetic approach. The pK(a) value was estimated as 7.23. The monodentate intermediate is assumed to rapidly react with endogenous compounds, resulting in a continuous conversion of oxaliplatin via the monodentate form.

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Alkaline hydrolysis of oxaliplatin—Isola
Alkaline hydrolysis of oxaliplatin—Isolation and identification of the oxalato monodentate intermediate
✍ Elin Jerremalm; Pernilla Videhult; Gunvor Alvelius; William J. Griffiths; Tomas 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

The alkaline degradation of the chemotherapeutic agent oxaliplatin has been studied using liquid chromatography. The oxalato ligand is lost in two consecutive steps. First, the oxalato ring is opened, forming an oxalato monodentate intermediate, as identified by electrospray ionization mass spectrom