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Hydrolysis of cocaine in human plasma by cholinesterase

โœ Scribed by David J. Stewart; Tadanobu Inaba; Bing K. Tang; Werner Kalow


Book ID
118938087
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
307 KB
Volume
20
Category
Article
ISSN
0024-3205

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In humans, the plasma enzyme butyrylcholinesterase, BChE (EC 3.1.1.8), mediates the in vivo plasma hydrolysis of cocaine to the pharmacologically inactive metabolite ecgonine methyl ester, EME. This enzyme has been purified from human plasma to investigate the potential as a treatment for cocaine in