Hydrolysis of Benzodiazepines in a Microwave Oven and Ultraviolet Derivative Analysis of Their Benzophenones

✍ Scribed by A. Moralesrubio; J.V. Julianortiz; A. Salvador; M. Delaguardia

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 308 KB
• Volume: 49
• Category: Article
• ISSN: 0026-265X
• DOI: 10.1006/mchj.1994.1003

✦ Synopsis

Oxazepam, clonazepam, lorazepam, nitrazepam, prazepam, and dipotassium chlorazepate have been quantitatively hydrolyzed in (6 \mathrm{M} \mathrm{HCl}) to their respective benzophenones using a microwave oven with (520 \mathrm{~W}) power and a digestion time of (8 \mathrm{~min}). The hydrolysis yield obtained in each case corresponds to (103,117,98,115,97), and (97 %), respectively. Chlorazepate has been used as a test molecule to evaluate the effect of the digestion parameters, such as power and digestion time, on the hydrolysis yield. To determine benzophenones in the presence of benzodiazepines, in order to establish the hydrolysis yield, derivative ultraviolet spectrometry has been employed, using the isodifferential approach. 1994 Academic Press, Inc.