In vitro and in vivo hydrolysis of salic
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Leo W. Brown; Arlington A. Forist
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Article
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1972
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John Wiley and Sons
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English
β 351 KB
The kinetics of hydrolysis of the carbamoyl group in salicylanilide N-methylcarbamate (I) and 4-biphenylyl N-methylcarbamate (11) showed that the reaction was first order with respect to both hydroxide ion and carbamate. At 37", the hydroxideion-catalyzed hydrolysis of 1 to yield salicylanilide (111