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Hydrolysis of 3,4-diphenyl-1,2,5-thiadiazole-1,1-dioxide. Acid and base catalysis

✍ Scribed by M. V. Mirifico; E. J. Vasini; J. E. Sicre

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 272 KB
Volume: 23
Category: Article
ISSN: 0538-8066
DOI: 10.1002/kin.550230302

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✦ Synopsis

We have performed a product and kinetic study of the hydrolysis of 3,4-diphenyl-1,2,5-thiadiazole-1,l-dioxide in aqueous solution. Benzil and sulfamide are the only products of hydrolysis and are formed in equimolar yields.

The kinetic results indicate that a first order law is followed up to 90% conversion. The observed rate constant is independent of substrate concentration.

Ionic strength and buffer concentration do not affect the rate constant, but the reaction is acid-base catalyzed. The rate-pH profile has been determined and a mechanism that fits the experimental data satisfactorily is proposed. Corresponding rate constants and equilibrium constants for the protonation of the substrate are reported.

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