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Hydrolysis in the absence of bulk water 2. Chemoselective hydrolysis of nitriles using tetrahalophthalic acids

โœ Scribed by William D. Rounds; Jefferson T. Eaton; John H. Urbanowicz; Gordon W. Gribble

Book ID
104217838
Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
216 KB
Volume
29
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The reaction of nitriles with tetrafluorophthalic or tetrachlorophthalic acid gives carboxylic acids in good yield. The reaction is chemoselective in that the nitrile functionality can be hydrolyzed in the presence of ester groups.

๐Ÿ“œ SIMILAR VOLUMES

Hydrolysis in the absence of bulk water
Hydrolysis in the absence of bulk water 1. Chemoselective hydrolysis of amides using tetrahalophthalic anhydrides
โœ Jefferson T. Eaton; William D. Rounds; John H. Urbanowicz; Gordon W. Gribble ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 252 KB

The reaction of primary and secondary amides with tetrafluorophthalic or tetrachlorophthalic anhydride gives carboxylic acids in good yield. The reaction is chemoselective in that the amide functionality can be hydrolyzed in the presence of ester groups. We report that the prototypical reaction bet