Hydrolysis and Cytotoxic Properties of Osmium(II)/(III)-DMSO-Azole Complexes. Short Communication
✍ Scribed by Alexander Egger; Berta Cebrián-Losantos; Iryna N. Stepanenko; Artem A. Krokhin; Rene Eichinger; Michael A. Jakupec; Vladimir B. Arion; Bernhard K. Keppler
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 256 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1612-1872
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✦ Synopsis
Abstract
The antiproliferative properties of the osmium(II) complexes cis,fac‐[Os^II^Cl~2~(DMSO)~3~(L)] and trans,cis,cis‐[Os^II^Cl~2~(DMSO)~2~(L)~2~] (L=1__H__‐pyrazole, 1__H__‐imidazole) were studied in three human cancer cell lines, namely 41M (ovary), SK‐BR‐3 (breast), and SW480 (colon). Their activities were compared with those of osmium(III) and ruthenium(III) NAMI‐A type complexes on HT‐29 (colon) and SK‐BR‐3 cancer cell lines. While IC~50~ values of all the Os^II^ complexes were found to be >1000 μM in all cell lines, Os and Ru‐NAMI‐A type complexes showed remarkable antiproliferative activity. The marginal in vitro cytotoxicity of the Os^II^ compounds is presumably attributed to their resistance to hydrolysis. However, the Os‐NAMI‐A complexes, which are also kinetically stable in aqueous solution, showed reasonable antiproliferative activity in vitro when compared with the analogous Ru compounds and with the Os^II^‐DMSO‐azole species, indicating that hydrolysis might be not a prerequisite for the antitumor activity of Os‐NAMI‐A type complexes.