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Hydrogenolysis of Steroid Thioacetals with Modified Raney Nickel Catalyst

✍ Scribed by Bernstein, Seymour; Dorfman, Louis


Book ID
127396106
Publisher
American Chemical Society
Year
1946
Tongue
English
Weight
239 KB
Volume
68
Category
Article
ISSN
0002-7863

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The effects of reaction variables (temperature, pressure, solvent type, substrate to catalyst ratio and substrate concentration) on enantioselectivity of methyl acetoacetate hydrogenation were studied. Raney nickel modified with (2R,3R)-(+)-tartaric acid was used as a catalyst. The reactions were ca