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Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

✍ Scribed by Dumont, Andreas; Hehner, Steffen P; Hofmann, Thomas G; Ueffing, Marius; Dröge, Wulf; Schmitz, M Lienhard


Book ID
110061782
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
601 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract Hyperglycemia‐induced generation of reactive oxygen species (ROS) can lead to cardiomyocyte apoptosis and cardiac dysfunction. However, the mechanism by which high glucose causes cardiomyocyte apoptosis is not clear. In this study, we investigated the signaling pathways involved in NADP